The efficacy of oral cyproterone acetate in combination with ethinyloestradiol in acne tarda of the facial type

@article{Gollnick1998TheEO,
  title={The efficacy of oral cyproterone acetate in combination with ethinyloestradiol in acne tarda of the facial type},
  author={H. Gollnick and M. Albring and K. Brill},
  journal={Journal of Dermatological Treatment},
  year={1998},
  volume={9},
  pages={71-79}
}
BACKGROUND: Cyproterone acetate is a potent antiandrogen with strong progestational activity. In combination with ethinyloestradiol, it has been shown to be of clinical benefit to women displaying signs of androgenization, such as acne, seborrhoea and hirsutism. In addition, this combined oestrogen/progestogen preparation provides effective contraceptive protection. OBJECTIVE: The aim of this open-label, multicentre study was to determine the efficacy and tolerability of a preparation… Expand
Safety Data and Beneficial Effects of the Combined Oral Contraceptive Ethinylestradiol 0.03 mg/Chlormadinone Acetate 2 mg (Belara®)
TLDR
The results re-affirmed the favourable ADR profile of the COC EE 0.03 mg/CMA 2 mg, as well as its good cycle control and beneficial effects on dysmenorrhoea, complaints typically occurring during the cycle, acne and well-being. Expand
Effects of an Oral Contraceptive Containing Chlormadinone and Ethinylestradiol on Acne-Prone Skin of Women of Different Age Groups
TLDR
The highly statistically significant improvements in clinical findings and various biophysical skin parameters observed in this study suggest that the antiandrogenic oral contraceptive chlormadinone/ethinylestradiol may be a major therapy option in women with acne-prone skin who request hormonal contraception. Expand
Oral contraceptives as anti-androgenic treatment of acne.
  • A. Lemay, Y. Poulin
  • Medicine
  • Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC
  • 2002
TLDR
The physician prescribing an OC as an anti-androgen intervention should take into account the multiple factors involved in acne and be familiar with current non-hormonal agents for treating mild to moderate acne. Expand
Oral contraceptives in the treatment of acne.
TLDR
The efficacy of these agents and their long-term safety profile supports their use in various grades of acne in females and their use as one of two preferred methods of contraception in patients with scarring and severe inflammatory acne being treated with systemic isotretinoin. Expand
Efficacy of an oral contraceptive containing EE 0.03 mg and CMA 2 mg (Belara) in moderate acne resolution: a randomized, double-blind, placebo-controlled Phase III trial.
TLDR
In addition to its contraceptive efficacy described elsewhere, EE/CMA is an effective treatment for moderate papulopustular acne and other androgen-related skin disorders. Expand
Hormonal Therapy of Acne
  • M. Haroun
  • Medicine
  • Journal of cutaneous medicine and surgery
  • 2004
TLDR
Hormonal therapy is an excellent choice for female patients with acne who have SAHA syndrome, polycystic ovarian syndrome, HAIRAN syndrome, hyper androgenism, insulin resistance, acanthosis nigricans, or cutaneous hyperandrogenism and may be combined to enhance therapeutic efficacy. Expand
Management of severe acne
TLDR
This review looks into the various options and latest approaches, and factors to consider, when combating severe acne, as well as other combination treatments. Expand
Antiandrogenic progestins for treatment of signs of androgenisation and hormonal contraception.
  • A. Schindler
  • Medicine
  • European journal of obstetrics, gynecology, and reproductive biology
  • 2004
TLDR
Under long-term treatment a favourable effect on carbohydrate and lipid metabolism can be seen due to the antiandrogenic properties of the progestins, and these combinations also correct menstrual cycle disturbances and thus reduce the incidence of anaemia. Expand
Current Concepts of the Pathogenesis of Acne
TLDR
Combination therapy using retinoids plus benzoyl peroxide or antibacterials can treat existing acne lesions faster than the individual agents alone and can also prevent the development of new lesions. Expand
Attitudes of Female Patients regarding Oral Contraceptives for Treatment of Acne
Background: Two hormonal agents with contraceptive properties are currently indicated in Canada for treatment of acne. Objective: The purpose of this study was to determine the attitudes and concernsExpand
...
1
2
...

References

SHOWING 1-10 OF 33 REFERENCES
Cyproterone Acetate Versus Levonorgestrel Combined with Ethinyl Estradiol in the Treatment of Acne: Results of a multicenter study *
  • L. Carlborg
  • Medicine
  • Acta obstetricia et gynecologica Scandinavica. Supplement
  • 1986
TLDR
DianeR mite is suggested as the treatment of choice in women with acne who are otherwise willing to use an oral contraceptive and support the previously unproven concept that regular oral contraceptive pills may improve acne in some women, whereas in others the condition was exacerbated. Expand
Acne: double blind clinical and laboratory trial of tetracycline, oestrogen-cyproterone acetate, and combined treatment.
TLDR
Adding antibiotics offers no advantage over using oestrogen-cyproterone on its own, although in this study the combination was more effective than tetracycline alone at six months. Expand
THE DEVELOPMENT AND EVALUATION OF AN OVULATION INHIBITOR (DIANE®) CONTAINING AN ANTIANDROGEN
  • U. Lachnit-Fixson
  • Medicine
  • Acta obstetricia et gynecologica Scandinavica. Supplement
  • 1979
TLDR
The preparation with the trade name Diane® has proven to be not only a reliable contraceptive, but also a very potent drug for the treatment of both acne and seborrhea, and of milder cases of hirsutism. Expand
[Cyproterone acetate - ethinylestradiol treatment of hirsutism, acne, seborrhea and alopecia].
TLDR
In most cases symptoms of virilization were significantly reduced, while untoward side effects were not noted, and patients were submitted to monitoring by means of a series of laboratory tests. Expand
Monophasic gestodene and ethinylestradiol in oral contraception: a multicenter open study
TLDR
The occurrence of side-effects most commonly associated with oral contraception showed a declarative decline, as demonstrated by the decline in the incidence of breakthrough bleeding and spotting, culminating in their eventual absence by the end of cycle 6. Expand
Cyproterone acetate as initial treatment and maintenance therapy for hirsutism.
TLDR
Levels of plasma testosterone, sex hormone binding globulin, free testosterone (derived) and androstenedione fell significantly on high dose CA and this reduction was maintained during low dose therapy and there was no significant deterioration in objective hirsutism grade or hair growth rate determined photographically. Expand
Pathogenesis and Pathogenesis Related Treatment of Acne
Acne is a disease of the second life decade with nearly 100% incidence among both females and males. Acne has an polyetiological background comprized of genetic, racial, endocrine, immunological,Expand
Oral spironolactone improves acne vulgaris and reduces sebum excretion
TLDR
The clinical response was dose‐dependent, with maximum subjective and objective benefit when spironolactone doses of 150–200 mg were used, but there was no correlation between sebum response and androgen status. Expand
Activity of the type 1 5 alpha-reductase exhibits regional differences in isolated sebaceous glands and whole skin.
TLDR
In the skin from older patients without acne the type 1 isozyme of 5 alpha-R predominates, its activity is concentrated in sebaceous glands and is significantly higher in seBaceous glands from the face and scalp compared to non-acne-prone areas, and the action of 13-cis retinoic acid in the control of acne is not at the level of 5alpha-R. Expand
Essential fatty acids and acne.
TLDR
A corollary hypothesis holds that low concentrations of linoleate in sebum impose a state of essential fatty acid deficiency on the cells of the follicular epithelium and induce the characteristic response of hyperkeratosis. Expand
...
1
2
3
4
...