The efficacy of long-term conjugated linoleic acid (CLA) supplementation on body composition in overweight and obese individuals: a systematic review and meta-analysis of randomized clinical trials

@article{Onakpoya2011TheEO,
  title={The efficacy of long-term conjugated linoleic acid (CLA) supplementation on body composition in overweight and obese individuals: a systematic review and meta-analysis of randomized clinical trials},
  author={Igho J. Onakpoya and Paul Posadzki and Leala K. Watson and Lucy Davies and Edzard Ernst},
  journal={European Journal of Nutrition},
  year={2011},
  volume={51},
  pages={127-134}
}
IntroductionNumerous supplements containing conjugated linoleic acid (CLA) are presently being promoted for body weight reduction. The aim of this systematic review is to evaluate the evidence for or against the long-term efficacy of CLA.MethodsElectronic searches were conducted to identify relevant randomized clinical trials (RCTs). No restrictions in age, time, or language were imposed. Studies had to be at least 6 months in duration. Three reviewers independently determined the eligibility… 

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Supplementation with conjugated linoleic acid for 24 months is well tolerated by and reduces body fat mass in healthy, overweight humans.

This study shows that CLA supplementation for 24 mo in healthy, overweight adults was well tolerated and confirms also that CLA decreases BFM in overweight humans, and may help maintain initial reductions in BFM and weight in the long term.

Efficacy of conjugated linoleic acid for reducing fat mass: a meta-analysis in humans.

A meta-analysis of human studies in which CLA was provided as a dietary supplement to test its efficacy in reducing fat mass indicated that the effect of CLA was linear for up to 6 mo and then slowly approached an asymptote at 2 y.

Conjugated linoleic acid supplementation for 1 y does not prevent weight or body fat regain.

A 3.4-g daily CLA supplementation for 1 y does not prevent weight or fat mass regain in a healthy obese population of moderately obese people.

Conjugated linoleic acid supplementation for 1 y reduces body fat mass in healthy overweight humans.

Long-term supplementation with CLA-FFA or CLA-triacylglycerol reduces BFM in healthy overweight adults, and adverse events did not differ significantly between groups.

Safety profile of conjugated linoleic acid in a 12-month trial in obese humans.

Six months supplementation with conjugated linoleic acid induces regional-specific fat mass decreases in overweight and obese

It is concluded that supplementation with CLA in healthy, overweight and obese adults decreases BFM in specific regions and is well tolerated.

Effect of conjugated linoleic acid on body fat accretion in overweight or obese children.

CLA supplementation for 7 +/- 0.5 mo decreased body fatness in 6-10-y-old children who were overweight or obese but did not improve plasma lipids or glucose and decreased HDL more than in the placebo group.

The effect of 6 months supplementation with conjugated linoleic acid on insulin resistance in overweight and obese

CLA does not affect glucose metabolism or insulin sensitivity in a population of overweight or obese volunteers and homeostasis model assessment (HOMA) and quantitative insulin sensitivity check index derived from fasting glucose and insulin were independent of treatment and time.

The role of conjugated linoleic acid in reducing body fat and preventing holiday weight gain

CLA supplementation among overweight adults significantly reduced body fat over 6 months and prevented weight gain during the holiday season and the rate of reported negative emotions decreased significantly with CLA, although there was no difference in any other category of adverse event.

Dietary supplementation with cis-9,trans-11 conjugated linoleic acid and aortic stiffness in overweight and obese adults.

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