The efficacy of combined use of intraarticular and intravenous tranexamic acid on reducing blood loss and transfusion rate in total knee arthroplasty.

@article{Lin2015TheEO,
  title={The efficacy of combined use of intraarticular and intravenous tranexamic acid on reducing blood loss and transfusion rate in total knee arthroplasty.},
  author={Sung-Yen Lin and Chung-Hwan Chen and Y. C. Fu and P J Huang and J K Chang and H. T. Huang},
  journal={The Journal of arthroplasty},
  year={2015},
  volume={30 5},
  pages={776-80}
}
The purpose of this study is to investigate the effect of preoperative intravenous (IV) and intraoperative topical administration of tranexamic acid (TXA) in total knee arthroplasty (TKA). A total of 120 patients were and randomly allocated to either topical group, combined group, or control group. The mean total blood loss was lower in the combined and topical groups (705 mL and 579 mL, respectively) in comparison with control group (949 mL, P < 0.001). There was a significant difference in… CONTINUE READING
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