The efficacy of certain anti-tuberculosis drugs is affected by binding to alpha-1-acid glycoprotein.

@article{Johnson2006TheEO,
  title={The efficacy of certain anti-tuberculosis drugs is affected by binding to alpha-1-acid glycoprotein.},
  author={David Evans Johnson and Kevin D. Smith},
  journal={Biomedical chromatography : BMC},
  year={2006},
  volume={20 6-7},
  pages={
          551-60
        }
}
One of the most ubiquitous plasma proteins, alpha-1-acid glycoprotein (AGP), has a high affinity, low capacity binding for basic drugs positively charged at physiological pH. Moreover, as an acute phase protein its level is increased in various disease states in a manner that is likely to influence the free plasma level of a drug, the ability to attain minimum effective concentration and overall in vivo effectiveness. AGP is a glycoprotein known to display disease specific changes in… CONTINUE READING
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