The efficacy of biological response modifiers against murine cytomegalovirus infection in normal and immunodeficient mice.

@article{Okada1987TheEO,
  title={The efficacy of biological response modifiers against murine cytomegalovirus infection in normal and immunodeficient mice.},
  author={Masayuki Okada and Yoichi Minamishima},
  journal={Microbiology and immunology},
  year={1987},
  volume={31 1},
  pages={45-57}
}
The host-mediated antiviral effect of two biological response modifiers (BRM), OK-432 and PS-K, against murine cytomegalovirus (MCMV) was evaluated in normal and immunologically deficient mice of the same litters. In normal littermate mice, BALB/c (nu/+) or C57BL/6 (bg/+), the BRM-induced resistance against MCMV infection was evidenced by increase in fifty percent lethal doses, decrease in titers of viruses replicated in the target organs and augmentation of natural killer (NK) cell activity of… CONTINUE READING

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