The efficacy of antigen processing is critical for protection against cytomegalovirus disease in the presence of viral immune evasion proteins.

@article{Holtappels2009TheEO,
  title={The efficacy of antigen processing is critical for protection against cytomegalovirus disease in the presence of viral immune evasion proteins.},
  author={Rafaela Holtappels and Doris Feltham Thomas and Matthias J Reddehase},
  journal={Journal of virology},
  year={2009},
  volume={83 18},
  pages={
          9611-5
        }
}
Cytomegaloviruses (CMVs) code for immunoevasins, glycoproteins that are specifically dedicated to interfere with the presentation of antigenic peptides to CD8 T cells. Nonetheless, the biological outcome is not an immune evasion of the virus, since CD8 T cells can control CMV infection even when immunoevasins are expressed. Here, we compare the processing of a protective and a nonprotective epitope derived from the same viral protein, the antiapoptotic protein M45 in the murine model. The data… CONTINUE READING

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