The efficacy of an IL-1alpha vaccine depends on IL-1RI availability and concomitant myeloid-derived suppressor cell reduction.

Abstract

We recently reported that tumor-derived interleukin (IL)-1beta strongly promotes tumor growth by inducing myeloid-derived suppressor cell (MDSC) and regulatory T-cell (T(reg)) expansion. To see whether redirection of an immune response can be achieved through immune response-supporting IL-1alpha application, IL-1RI competent (IL-1RI(comp)) and IL-1RI… (More)
DOI: 10.1097/CJI.0b013e31819b7b9e

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@article{Weiss2009TheEO, title={The efficacy of an IL-1alpha vaccine depends on IL-1RI availability and concomitant myeloid-derived suppressor cell reduction.}, author={Tobias Weiss and Mario Vitacolonna and Margot Zoeller}, journal={Journal of immunotherapy}, year={2009}, volume={32 6}, pages={552-64} }