The efficacy of afamelanotide and narrowband UV-B phototherapy for repigmentation of vitiligo.
@article{Grimes2013TheEO, title={The efficacy of afamelanotide and narrowband UV-B phototherapy for repigmentation of vitiligo.}, author={P. Grimes and I. Hamzavi and M. Lebwohl and J. Ortonne and H. Lim}, journal={JAMA dermatology}, year={2013}, volume={149 1}, pages={ 68-73 } }
BACKGROUND
Vitiligo is characterized by depigmented patches of skin due to loss of cutaneous melanocytes. Many recent studies have demonstrated defects in the melanocortin system in patients with vitiligo, including decreased circulating and lesional skin levels of α-melanocyte-stimulating hormone (α-MSH). Afamelanotide is a potent and longer-lasting synthetic analogue of naturally occurring α-MSH.
OBSERVATIONS
We describe the preliminary results of 4 patients with generalized vitiligo who… CONTINUE READING
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References
SHOWING 1-10 OF 42 REFERENCES
PUVA‐induced repigmentation of vitiligo: a histochemical (split‐DOPA) and ultrastructural study
- Medicine
- The British journal of dermatology
- 1979
- 100
Vitiligo: pathogenetic hypotheses and targets for current therapies.
- Biology, Medicine
- Current drug metabolism
- 2010
- 71
Indications and action mechanisms of phototherapy.
- Biology, Medicine
- Journal of dermatological science
- 2000
- 50
The melanocortin-1 receptor is a key regulator of human cutaneous pigmentation.
- Biology, Medicine
- Pigment cell research
- 2000
- 116
- PDF
Autoimmune destruction of skin melanocytes by perilesional T cells from vitiligo patients.
- Medicine
- The Journal of investigative dermatology
- 2009
- 287