The efficacy and safety of terazosin for the treatment of symptomatic BPH

@article{Lepor1991TheEA,
  title={The efficacy and safety of terazosin for the treatment of symptomatic BPH},
  author={Herbert Lepor and Dan C. Henry and A. R. Laddu},
  journal={The Prostate},
  year={1991},
  volume={18}
}
At least 16 clinical investigations have documented the effectiveness of alpha blockade for BPH. In the present review, four clinical studies evaluating the efficacy and safety of terazosin, a selective long‐acting alpha1 blocker, for symptomatic BPH are reviewed. The unique features of these clinical investigations are: the study designs established detailed inclusion and exclusion criteria, the outcome assessments were based upon quantitative outcome parameters, large cohorts of homogeneous… 
42 Citations
The safety, efficacy and compliance of terazosin therapy for benign prostatic hyperplasia.
TLDR
The study demonstrates the safety, efficacy and compliance of terazosin therapy for BPH during a 2-year followup.
Long-term efficacy and safety of terazosin in patients with benign prostatic hyperplasia*
TLDR
This study suggests that terazosin is well tolerated and effective in long-term treatment of patients with BPH, with peak urinary flow rates significantly higher than baseline values.
A randomized, placebo-controlled multicenter study of the efficacy and safety of terazosin in the treatment of benign prostatic hyperplasia.
TLDR
This study unequivocally demonstrates the safety and efficacy of terazosin for the treatment of symptomatic BPH, and selective alpha 1-blockade is likely to gain widespread acceptance for the Treatment of BPH due to itssafety and efficacy.
The Hytrin Community Assessment Trial study: a one-year study of terazosin versus placebo in the treatment of men with symptomatic benign prostatic hyperplasia. HYCAT Investigator Group.
TLDR
Terazosin given once daily in a dose ranging from 2 to 10 mg in community-based urology practices under conditions simulating usual care is effective in reducing the symptoms, perception of bother, and the impairment of QQL due to urinary symptoms in men with moderate to severe symptoms of prostatism.
Terazosin in the treatment of benign prostatic hyperplasia: a multicentre, placebo-controlled trial.
TLDR
Terazosin was well tolerated by patients in this study and may provide symptomatic relief in patients with BPH and was well administered in a multicentre, randomised, placebo-controlled trial involving patients with symptomatic bladder outflow obstruction.
Study design of the Medical Therapy of Prostatic Symptoms (MTOPS) trial.
TLDR
The design of the MTOPS trial, the concept of BPH progression, the definition and methods of determining the primary outcome events and the proposed statistical analysis methods are described.
Terazosin in benign prostatic hyperplasia: effects on blood pressure in normotensive and hypertensive men.
  • R. Kirby
  • Medicine
    British journal of urology
  • 1998
TLDR
Terazosin is a safe treatment for BPH in normotensive and hypertensive men, including men who are already taking additional antihypertensive drugs, and it did not adversely affect patients receiving concomitant anti Hypertensive medication.
A multicenter, randomized, double-blind, placebo-controlled study to evaluate the safety and efficacy of terazosin in the treatment of benign prostatic hyperplasia.
TLDR
Overall, this study showed terazosin to be safe and effective in relieving the signs and symptoms of BPH and should be considered as a treatment alternative.
The emerging role of alpha antagonists in the therapy of benign prostatic hyperplasia.
  • H. Lepor
  • Medicine
    Journal of andrology
  • 1991
TLDR
The preliminary experiences with alpha blockers for the treatment of BPH has been very encouraging, yet, the definitive role of alpha blockade in BPH awaits the reporting of multicenter, randomized placebo-controlled studies.
Long-term drug treatment of benign prostatic hyperplasia - results of a prospective 3-year multicenter study using Sabal extract IDS 89.
  • D. Bach, L. Ebeling
  • Medicine
    Phytomedicine : international journal of phytotherapy and phytopharmacology
  • 1996
TLDR
The clinical status of BPH and thus the quality of life of 4 out of 5 patients was markedly improved by long-term IDS 89 therapy and the deterioration rate at the end of the 3-year treatment period was significantly lower than in untreated BPH subjects.
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