The efficacy and safety of oxandrolone treatment for patients with severe burns: A systematic review and meta-analysis.

@article{Li2016TheEA,
  title={The efficacy and safety of oxandrolone treatment for patients with severe burns: A systematic review and meta-analysis.},
  author={Hui Li and Yinan Guo and Zhenyu Yang and Mridul Roy and Qu-lian Guo},
  journal={Burns : journal of the International Society for Burn Injuries},
  year={2016},
  volume={42 4},
  pages={
          717-27
        }
}
  • Hui Li, Yinan Guo, Q. Guo
  • Published 1 June 2016
  • Medicine
  • Burns : journal of the International Society for Burn Injuries

A Reappraisal of Oxandrolone in Burn Management

Future clinical trials are needed using larger sample sizes and long-term follow-up to determine whether oxandrolone in the context of rehabilitation programs can reduce mortality, lower treatment costs, and improve function outcomes among burn patients.

Assessment of the impact of oxandrolone on outcomes in burn injured patients.

Incidence of oxandrolone induced hepatic transaminitis in patients with burn injury.

Risk Factors Associated with the Development of Transaminitis in Oxandrolone-Treated Adult Burn Patients.

Patients who are younger and have concurrent amiodarone or vasopressor use have the highest risk of developing oxandrolone induced transaminitis and should be monitored closely.

Oxandrolone Efficacy in Wound Healing in Burned and Decubitus Ulcer Patients: A Systematic Review

Analysis of the available data demonstrated a significant advantage in skin healing using oxandrolone in adult burn patients as an adjunct, and for adult patients with pressure ulcers, the drug showed no benefit on wound healing and skin graft site healing.

Investigation into Possible Association of Oxandrolone and Heterotopic Ossification Following Burn Injury.

In the mouse model, while there was a trend toward the oxandrolone group developing a greater volume of HO, this did not reach statistical significance and there was no significant difference between rates of elbow HO between the two populations.

Application of beta-blockers in burn management

Propranolol continues to be the most effective therapy for reducing the hypermetabolic response and other morbidities resulting from burn injuries.

Dehydroepiandrosterone: a potential therapeutic agent in the treatment and rehabilitation of the traumatically injured patient

There are no DHEA or DHEAS supplementation studies in trauma patients, but the evidence for this potential therapeutic agent in the treatment and rehabilitation of the severely injured patient is reviewed.

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Oxandrolone use in adult burn patients. Systematic review and meta-analysis.

The analysis of the available data demonstrated significant benefits considering lesser loss of corporal mass, lesser nitrogen loss, and shorter donor area healing time, when Oxandrolone was used, comparatively with the control group (placebo or not).

Impact of Oxandrolone Treatment on Acute Outcomes After Severe Burn Injury

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  • 2008
Examination of early oxandrolone treatment in this cohort of severely burned adults suggests that this therapy is safe and may be associated with improved survival, and further studies are necessary to define the exact mechanisms by which ox androlone is beneficial during inpatient treatment.

Effects of Oxandrolone on Outcome Measures in the Severely Burned: A Multicenter Prospective Randomized Double-Blind Trial

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    Journal of burn care & research : official publication of the American Burn Association
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Treatment using oxandrolone should be considered for use in the severely burned while hepatic transaminases are monitored, and length of stay was shorter in the ox androlone group than placebo.

Incidence of Hepatic Dysfunction Is Equivalent in Burn Patients Receiving Oxandrolone and Controls

There appears no significant increased incidence of hepatic dysfunction in burn patients who received oxandrolone compared to those who did not, and the study and control groups were similar in age and burn size.

The Effect of Oxandrolone on the Endocrinologic, Inflammatory, and Hypermetabolic Responses During the Acute Phase Postburn

In this large prospective, double-blinded, randomized single-center study, oxandrolone shortened length of acute hospital stay, maintained LBM, improved body composition and hepatic protein synthesis while having no adverse effects on the endocrine axis postburn, but was associated with an increase in AST and ALT.

The long-term effect of oxandrolone on hepatic acute phase proteins in severely burned children.

Treatment with oxandrolone in severe burns significantly increases constitutive protein and reduces acute phase protein levels.

Comparison of the anabolic effects and complications of human growth hormone and the testosterone analog, oxandrolone, after severe burn injury.

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    Burns : journal of the International Society for Burn Injuries
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Metabolic and Hormonal Changes of Severely Burned Children Receiving Long-Term Oxandrolone Treatment

Oxandrolone improved body composition and strength in severely burned children during the 12 months of treatment and its effect on height and weight continued after treatment was discontinued.

The anticatabolic and wound healing effects of the testosterone analog oxandrolone after severe burn injury.

The anabolic agent, oxandrolone, significantly decreased weight loss and net nitrogen loss and increased donor site wound healing compared with placebo controls and there were no complications with the use of ox androlone.