The efficacy and safety of oxandrolone treatment for patients with severe burns: A systematic review and meta-analysis.

@article{Li2016TheEA,
  title={The efficacy and safety of oxandrolone treatment for patients with severe burns: A systematic review and meta-analysis.},
  author={Hui Li and Yinan Guo and Zhenyu Yang and Mridul Roy and Qu-lian Guo},
  journal={Burns : journal of the International Society for Burn Injuries},
  year={2016},
  volume={42 4},
  pages={
          717-27
        }
}
  • Hui Li, Yinan Guo, Q. Guo
  • Published 1 June 2016
  • Medicine
  • Burns : journal of the International Society for Burn Injuries
A Reappraisal of Oxandrolone in Burn Management
TLDR
Future clinical trials are needed using larger sample sizes and long-term follow-up to determine whether oxandrolone in the context of rehabilitation programs can reduce mortality, lower treatment costs, and improve function outcomes among burn patients.
Assessment of the impact of oxandrolone on outcomes in burn injured patients.
Incidence of oxandrolone induced hepatic transaminitis in patients with burn injury.
Risk Factors Associated with the Development of Transaminitis in Oxandrolone-Treated Adult Burn Patients.
TLDR
Patients who are younger and have concurrent amiodarone or vasopressor use have the highest risk of developing oxandrolone induced transaminitis and should be monitored closely.
Investigation into Possible Association of Oxandrolone and Heterotopic Ossification Following Burn Injury.
TLDR
In the mouse model, while there was a trend toward the oxandrolone group developing a greater volume of HO, this did not reach statistical significance and there was no significant difference between rates of elbow HO between the two populations.
Application of beta-blockers in burn management
TLDR
Propranolol continues to be the most effective therapy for reducing the hypermetabolic response and other morbidities resulting from burn injuries.
Dehydroepiandrosterone: a potential therapeutic agent in the treatment and rehabilitation of the traumatically injured patient
TLDR
There are no DHEA or DHEAS supplementation studies in trauma patients, but the evidence for this potential therapeutic agent in the treatment and rehabilitation of the severely injured patient is reviewed.
The Endocrine and Metabolic Response in Male Survivors of Major Trauma
TLDR
The acute catabolic response to severe injury is accompanied by sustained androgen suppression, and the impact of androgen supplementation on health outcomes after major trauma should be systematically explored.
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References

SHOWING 1-10 OF 37 REFERENCES
Oxandrolone use in adult burn patients. Systematic review and meta-analysis.
TLDR
The analysis of the available data demonstrated significant benefits considering lesser loss of corporal mass, lesser nitrogen loss, and shorter donor area healing time, when Oxandrolone was used, comparatively with the control group (placebo or not).
Impact of Oxandrolone Treatment on Acute Outcomes After Severe Burn Injury
  • T. Pham, M. Klein, D. Herndon
  • Medicine, Psychology
    Journal of burn care & research : official publication of the American Burn Association
  • 2008
TLDR
Examination of early oxandrolone treatment in this cohort of severely burned adults suggests that this therapy is safe and may be associated with improved survival, and further studies are necessary to define the exact mechanisms by which ox androlone is beneficial during inpatient treatment.
Effects of Oxandrolone on Outcome Measures in the Severely Burned: A Multicenter Prospective Randomized Double-Blind Trial
  • S. Wolf, L. Edelman, J. Saffle
  • Medicine
    Journal of burn care & research : official publication of the American Burn Association
  • 2006
TLDR
Treatment using oxandrolone should be considered for use in the severely burned while hepatic transaminases are monitored, and length of stay was shorter in the ox androlone group than placebo.
Incidence of Hepatic Dysfunction Is Equivalent in Burn Patients Receiving Oxandrolone and Controls
TLDR
There appears no significant increased incidence of hepatic dysfunction in burn patients who received oxandrolone compared to those who did not, and the study and control groups were similar in age and burn size.
The impact of oxandrolone on length of stay following major burn injury: a clinical practice evaluation.
The Effect of Oxandrolone on the Endocrinologic, Inflammatory, and Hypermetabolic Responses During the Acute Phase Postburn
TLDR
In this large prospective, double-blinded, randomized single-center study, oxandrolone shortened length of acute hospital stay, maintained LBM, improved body composition and hepatic protein synthesis while having no adverse effects on the endocrine axis postburn, but was associated with an increase in AST and ALT.
The long-term effect of oxandrolone on hepatic acute phase proteins in severely burned children.
TLDR
Treatment with oxandrolone in severe burns significantly increases constitutive protein and reduces acute phase protein levels.
Comparison of the anabolic effects and complications of human growth hormone and the testosterone analog, oxandrolone, after severe burn injury.
  • R. Demling
  • Medicine, Biology
    Burns : journal of the International Society for Burn Injuries
  • 1999
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