The efficacy and safety of oral immediate-release oxymorphone for postsurgical pain.

@article{Gimbel2004TheEA,
  title={The efficacy and safety of oral immediate-release oxymorphone for postsurgical pain.},
  author={Joseph S Gimbel and Harry Ahdieh},
  journal={Anesthesia and analgesia},
  year={2004},
  volume={99 5},
  pages={1472-7; table of contents}
}
In this double-blind, parallel-group study, we compared 3 oxymorphone immediate-release (IR) doses with placebo for efficacy and with oxycodone IR and placebo for safety in patients with acute moderate-to-severe postsurgical pain. During the single-dose phase (n = 300), patients received oxymorphone IR 10, 20, or 30 mg; oxycodone IR 10 mg; or placebo. All oxymorphone IR doses were superior for providing pain relief for 8 h (P < 0.05), with a significant analgesic dose response (P < 0.001… CONTINUE READING

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