The efficacy and safety of nine South African medicinal plants in controlling Bacillus anthracis Sterne vaccine strain

  title={The efficacy and safety of nine South African medicinal plants in controlling Bacillus anthracis Sterne vaccine strain},
  author={Ishaku Leo Elisha and Jean Paul Dzoyem and Francien Susanna Botha and Jacobus Nicolaas Eloff},
  journal={BMC Complementary and Alternative Medicine},
BackgroundAnthrax is a zoonotic disease caused by Bacillus anthracis, a Gram-positive spore-forming bacterium. The presence of the bacteria and the toxins in the blood of infected hosts trigger a cascade of pathological events leading to death. Nine medicinal plants with good activities against other bacteria were selected to determine their in vitro antibacterial activity against Bacillus anthracis Sterne strain. The cytotoxicity of the extracts on Vero kidney cells was also determined… 
Potency and selectivity indices of acetone leaf extracts of nine selected South African trees against six opportunistic Enterobacteriaceae isolates from commercial chicken eggs
Cremaspora triflora extracts had good activity against all the pathogenic egg isolates, with the exception of Proteus mirabilis, suggesting that the plant has potential as a therapeutic agent against some members of the Enterobacteriaceae.
Acetone leaf extracts of some South African trees with high activity against Escherichia coli also have good antimycobacterial activity and selectivity index
The high activity of C. triflora extracts against the fast-growing mycobacteria and good cellular safety is promising and it may be interesting to investigate extracts against pathogenic M. tuberculosis, M. bovis and M. avium cultures and to isolate active antimycobacterial compounds.
The antibacterial activity of extracts of nine plant species with good activity against Escherichia coli against five other bacteria and cytotoxicity of extracts
A weak positive, but statistically non-significant correlation between the potency of the extracts and their cytotoxicity is found and it does not appear that activity against E. coli is a good predictor of activity against Gram-negative rather than Gram-positive bacteria.
Distribution and molecular characterization of South African Bacillus Anthracis strains and their associated bacteriophages
An environmental risk/isolation survey was carried out in 2012 to determine the efficacy of control measures employed during the 2008 anthrax outbreak, and found no B. anthracis could be isolated from the old carcass sites, even when bone fragments from the carcasses were still clearly evident.
Isolation of anti-mycobacterial compounds from Curtisia dentata (Burm.f.) C.A.Sm (Curtisiaceae)
The derivatives had better antimicrobial activity and low cytotoxic effects compared to isolated compounds, and it appears that acetylation of both betulinic acid and ursolic acid increased their activity against the selected Mycobacterium species.
Common Garlic (Allium sativum) has Potent Anti-Bacillus anthracis Activity among Various Commonly Used Spices and Herbs
It is hypothesize that some of the commonly available plants in poor endemic areas which are used as food and also employed in traditional medicine may have potent anti- Bacillus anthracis activity in a form amenable to use in the endemic areas.
A strategy to decrease vectorial competence of dengue mosquito Aedes aegypti by alteration of its gut microbiota using Indian traditional medicinal plants
The results indicate that the plants used in the present study possessed antimicrobial activities against gut microbes of Ae.
  • J. Erhabor, M. Idu
  • Chemistry
    Journal of Microbiology, Biotechnology and Food Sciences
  • 2020
The results of the biological activities of AB root is an indication of its potential use in drug development for the management of infectious diseases and other related ailments.
Phytochemical Composition, Proximate Analysis and Antimicrobial Screening of the Methanolic Extract of Diospyros mespiliformis Hochst ex a. Dc (ebenaceae)
Preliminary screening of the methanolic leaf extract of D. mespiliformis was carried out for its phytochemical and proximate constituents in addition to investigating its antimicrobial activity against four bacteria species, showing broad spectrum anti microbial activity in a dose dependent manner.
Common Garlic (Allium sativum L.) has Potent Anti-Bacillus anthracis Activity
Garlic (Allium sativum L.) extract was identified as the most promising candidate with bactericidal activity against B. anthracis and was assessed for its thermostability, stability under pH extremes encountered in the gastrointestinal tract, and potential antagonistic interaction with bile salts as well as the FDA-approved antibiotics used for anthrax control.


Which tree orders in southern Africa have the highest antimicrobial activity and selectivity against bacterial and fungal pathogens of animals?
  • E. Pauw, J. Eloff
  • Biology, Medicine
    BMC Complementary and Alternative Medicine
  • 2014
Against all classes of microorganisms, the four orders containing species with the highest average antimicrobial activities also contained several species with low activities against different pathogens and vice versa.
Antimicrobial activity of Gunnera perpensa and Heteromorpha arborescens var. abyssinica
Methanol and water extracts from Gunnera perpensa rhizomes and Heteromorpha arborescens roots were investigated for their in vitro antimicrobial activities and both plant species were active against the Gram positive bacteria and fungi.
Antibacterial, anti-HIV-1 protease and cytotoxic activities of aqueous ethanolic extracts from Combretum adenogonium Steud. Ex A. Rich (Combretaceae)
Results provide promising baseline information for the potential development of C. adenogonium extracts in treatment of bacterial and HIV/AIDS-related opportunistic infections.
Selection of Bacillus anthracis isolates resistant to antibiotics.
The ease with which B. anthracis can be made resistant in vitro suggests that close monitoring of patients treated for anthrax is mandatory and cross-resistance to fluoroquinolones did not correlate with resistance to other antibiotics.
Antiplasmodial and cytotoxic activities of flavonoids and arylbenzofuran derivatives from Morus mesozygia
It was found that all compounds were active against the FcB1 strain of Plasmodium with artocarpesin, koushenol E and mulberrofuran F showing particular potency.
In vitro resistance of Bacillus anthracis Sterne to doxycycline, macrolides and quinolones.
Antifungal activities of six South African Terminalia species (Combretaceae).