The efficacy and safety of dual orexin receptor antagonists in primary insomnia: A systematic review and network meta-analysis.

@article{Xue2021TheEA,
  title={The efficacy and safety of dual orexin receptor antagonists in primary insomnia: A systematic review and network meta-analysis.},
  author={Tao Xue and Xin Wu and Shujun Chen and Yanbo Yang and Zeya Yan and Zhaoming Song and Wei Zhang and Jianguo Zhang and Zhouqing Chen and Zhong Wang},
  journal={Sleep medicine reviews},
  year={2021},
  volume={61},
  pages={
          101573
        }
}

Orexin Receptor Antagonists and Insomnia

We review recent evidence on the use of orexin receptor antagonists (ORAs) for treating insomnia. We evaluate studies on five dual ORAs and one selective ORA. Research on suvorexant in recent years

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TLDR
Two‐night oral administration of almorexant was effective and well tolerated in treating primary insomnia in elderly patients, and no unexpected safety concerns were identified.

Orexin Receptor Antagonism, a New Sleep-Enabling Paradigm: A Proof-of-Concept Clinical Trial

TLDR
Almorexant consistently and dose‐dependently improved sleep variables and may offer a new treatment approach for primary insomnia.

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TLDR
The data suggest that orexin receptor antagonism offers a novel approach to treating insomnia, and Class I evidence that suvorexant improves sleep efficiency over 4 weeks in nonelderly adult patients with primary insomnia.

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TLDR
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TLDR
Orexin receptor antagonism by filorexant significantly improved sleep efficiency in nonelderly patients with insomnia and was generally well tolerated.

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TLDR
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TLDR
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TLDR
LEM5 and LEM10 provided significant benefit on sleep onset and sleep maintenance in individuals with insomnia disorder versus placebo, and was well tolerated.