The efficacy and safety of aripiprazole for tic disorders in children and adolescents: A systematic review and meta-analysis

@article{Wang2017TheEA,
  title={The efficacy and safety of aripiprazole for tic disorders in children and adolescents: A systematic review and meta-analysis},
  author={Shuai Wang and Yan Wei and Jian-hong Yang and Yu-ming Zhou and Yu-hang Cheng and Chao Yang and Yi Zheng},
  journal={Psychiatry Research},
  year={2017},
  volume={254},
  pages={24-32}
}

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References

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Aripiprazole for the treatment of tic disorders in children: a systematic review and meta-analysis

TLDR
Aripiprazole appears to be a promising therapy for children with tic disorders, and well-conducted RCTs are required to confirm this issue.

Systemic review of aripiprazole for the treatment of children and adolescents with tic disorders.

TLDR
Current evidence suggests that aripiprazole is effective for treating tic and Tourette disorders in both children and adolescents, and it seems that its adverse effect profile is safer than pimozide and some other antipsychotics.

Effectiveness and tolerability of aripiprazole in children and adolescents with Tourette's disorder: a pilot study in China.

TLDR
In this preliminary open-label trial, aripiprazole showed effectiveness in treating tic symptoms without causing significant weight gain or other serious side effects and could be an option for TD cases that do not respond to conventional therapies.

[A control study of aripiprazole and tiapride treatment for tic disorders in children].

TLDR
Low dose aripiprazole is safe and effective for treatment of tic disorders in children, suggesting that it represents a new valid option for the treatment ofTic disorder.

[A multicenter controlled study on aripiprazole treatment for children with Tourette syndrome in China].

TLDR
Aripiprazole was safe and well tolerated in Chinese population, and can be considered as a new valid option for the treatment of tic disorders.

A comparative study of aripiprazole and Haloperidol treatment for tic disorders in children

TLDR
Aripiprazole may be a promising drug in the treatment among children with tic disorders because of its high efficacy and less tolerability.

Aripiprazole Versus Risperidone for Treating Children and Adolescents with Tic Disorder: A Randomized Double Blind Clinical Trial

TLDR
Both aripiprazole and risperidone decreased the Yale Global Tic Severity Scale score during this trial and both medications increased the health related quality of life score.

Open-label study comparing the efficacy and tolerability of aripiprazole and haloperidol in the treatment of pediatric tic disorders

TLDR
Results indicate that aripiprazole may be a promising drug in the treatment of children and adolescents with tic disorders and further controlled studies are needed to determine the efficacy and tolerability of the drug in these patients.

A multicenter, randomized, double-blind, placebo-controlled study of aripiprazole in children and adolescents with Tourette's disorder.

TLDR
In comparison with placebo, aripiprazole was efficacious, generally tolerated and safe in the short-term treatment of children and adolescents with Tourette's disorder.

Tolerability profile of aripiprazole in patients with Tourette syndrome

TLDR
The prevalence of adverse effects appears to increase with treatment duration and the discontinuation rate of 20.7% suggests that aripiprazole is safe and reasonably well tolerated for use in TS.