The effects of yohimbine on exploratory and locomotor behaviour are attributable to its effects at noradrenaline and not at benzodiazepine receptors.

@article{Chopin1986TheEO,
  title={The effects of yohimbine on exploratory and locomotor behaviour are attributable to its effects at noradrenaline and not at benzodiazepine receptors.},
  author={Philippe Chopin and Sharon Pellow and S. E. File},
  journal={Neuropharmacology},
  year={1986},
  volume={25 1},
  pages={53-7}
}
A recent study has shown that the alpha 2-adrenoceptor antagonist, yohimbine, has an additional action, in micromolar concentrations, to inhibit the binding of [3H]benzodiazepines to their receptors in the CNS. An important question raised by this finding is to what extent the behavioural effects of yohimbine can be attributed to this action. Yohimbine (1.25-2.5 mg/kg) produced a dose-related decrease in exploratory head-dipping and locomotor activity in the holeboard test. The alpha 2… CONTINUE READING

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