The effects of yohimbine and amphetamine on fear expression and extinction in rats

@article{Mueller2009TheEO,
  title={The effects of yohimbine and amphetamine on fear expression and extinction in rats},
  author={Devin Mueller and Lening A. Olivera-Figueroa and Daniel S. Pine and Gregory J Quirk},
  journal={Psychopharmacology},
  year={2009},
  volume={204},
  pages={599-606}
}
Psychostimulants, such as yohimbine and amphetamine, can enhance learning and memory. Extinction of conditioned fear involves new learning, so we asked whether psychostimulants could enhance this learning. Previous work suggests that yohimbine facilitates extinction, using freezing as a fear measure. However, psychostimulant-induced alterations in locomotion can confound freezing measurements. Furthermore, the effects of amphetamine on fear extinction have never been examined. We evaluated the… CONTINUE READING

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