The effects of vitamin and mineral supplementation on symptoms of schizophrenia: a systematic review and meta-analysis

@article{Firth2017TheEO,
  title={The effects of vitamin and mineral supplementation on symptoms of schizophrenia: a systematic review and meta-analysis},
  author={Joseph Firth and B. Stubbs and Jerome Sarris and Simon Rosenbaum and Scott B. Teasdale and Michael Berk and Alison Ruth Yung},
  journal={Psychological Medicine},
  year={2017},
  volume={47},
  pages={1515 - 1527}
}
Background When used as an adjunctive with antipsychotics, certain vitamins and minerals may be effective for improving symptomatic outcomes of schizophrenia, by restoring nutritional deficits, reducing oxidative stress, or modulating neurological pathways. Method We conducted a systematic review of all randomized controlled trials (RCTs) reporting effects of vitamin and/or mineral supplements on psychiatric symptoms in people with schizophrenia. Random-effects meta-analyses were used to… 

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The efficacy and safety of nutrient supplements in the treatment of mental disorders: a meta‐review of meta‐analyses of randomized controlled trials

  • J. FirthS. Teasdale J. Sarris
  • Psychology, Medicine
    World psychiatry : official journal of the World Psychiatric Association
  • 2019
Clinicians should be informed of the nutrient supplements with established efficacy for certain conditions (such as eicosapentaenoic acid in depression), but also made aware of those currently lacking evidentiary support, to further elucidate the underlying mechanisms.

Nutritional supplements in psychotic disorders.

It is hoped that the initiation of personalized medicine strategies, such as stratification and using a clinical staging approach, will make it possible to identify the subgroups of patients who can obtain maximum benefit from dietary and nutritional interventions.

Nutritional psychiatry: the present state of the evidence

Preliminary clinical evidence that dietary interventions in clinically diagnosed populations are feasible and can provide significant clinical benefit is provided, and nutraceuticals including n-3 fatty acids, folate, S-adenosylmethionine, N-acetyl cysteine and probiotics are promising avenues for future research.
...

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