The effects of veratramine on atrio-ventricular nodal rhythm and on auricular flutter in the dog heart-lung preparation

@article{Benforado2004TheEO,
  title={The effects of veratramine on atrio-ventricular nodal rhythm and on auricular flutter in the dog heart-lung preparation},
  author={Joseph M. Benforado and Julia D{\"o}rner and J. Fuentes},
  journal={Naunyn-Schmiedebergs Archiv f{\"u}r experimentelle Pathologie und Pharmakologie},
  year={2004},
  volume={240},
  pages={382-393}
}
ZusammenfassungIn zwölf Herz-Lungenpräparaten (HLP) des Hundes wurde durch Zerstörung des S-A-Knotens A-V-Rhythmus erzeugt. Der Mittelwert der Herzfrequenzsabnahme betrug 100 Schläge pro Minute. Ephedrin bis zur Gesamtdosis von 3 mg führte zu einem Mittelwert der Maximalfrequenz von 187/min, entsprechend einer mittleren maximalen Frequenzzunahme von 140/min. Die log-Dosis-Wirkungskurve für Ephedrin bei S-A- und A-V-Rhythmus verliefen ähnlich. Die 50% der Maximalwirkung hervorrufende Dosis… 
The Bezold‐Jarisch Reflex in the Conscious Dog
TLDR
It is indicated that the chemical stimulation of left ventricular receptors in the conscious dog mediates a bradycardia, hypotension and decrease in total peripheral resistance which is produced by sympathetic withdrawal as well as cholinergic vasodilation.

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TLDR
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