The effects of venlafaxine on autonomic functions in healthy volunteers.

  title={The effects of venlafaxine on autonomic functions in healthy volunteers.},
  author={Timo Siepmann and Tjalf Ziemssen and Michael Mueck-Weymann and Wilhelm Kirch and Martin Siepmann},
  journal={Journal of clinical psychopharmacology},
  volume={27 6},
Antidepressants that block norepinephrine uptake may cause unwanted effects on autonomic functions such as reduction of heart rate variability. This randomized, double-blind, placebo-controlled study examined the effects of venlafaxine on heart rate variability, vasoconstrictory responses (VRs) of cutaneous blood vessels, and pupillary light reflex in humans. Twelve healthy male subjects aged 23 to 32 years (mean +/- SD, 26 +/- 3 years) orally received 37.5 mg of venlafaxine BID for 7 days and… CONTINUE READING


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