The effects of vanadate and molybdate on cathepsin D; relationship to ATP activation of lysosomal proteolysis.

Abstract

The effects of the phosphate analogues, vanadate and molybdate, on the ATP-activated enzyme, cathepsin D, were investigated. Both were found to inhibit proteolysis but this appeared to be the result of non-specific interactions with the protein substrates which result in precipitation, rather than interactions with the enzyme. Inhibition of proteolysis was… (More)

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Cite this paper

@article{Pillai1985TheEO, title={The effects of vanadate and molybdate on cathepsin D; relationship to ATP activation of lysosomal proteolysis.}, author={Sabitha Pillai and James E. Zull}, journal={Cell biology international reports}, year={1985}, volume={9 12}, pages={1091-6} }