The effects of twelve weeks of bed rest on bone histology, biochemical markers of bone turnover, and calcium homeostasis in eleven normal subjects.

@article{Zerwekh1998TheEO,
  title={The effects of twelve weeks of bed rest on bone histology, biochemical markers of bone turnover, and calcium homeostasis in eleven normal subjects.},
  author={Joseph E. Zerwekh and Lisa A. Ruml and Frank A Gottschalk and Charles Pak},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={1998},
  volume={13 10},
  pages={
          1594-601
        }
}
This study was undertaken to examine the effects of 12 weeks of skeletal unloading on parameters of calcium homeostasis, calcitropic hormones, bone histology, and biochemical markers of bone turnover in 11 normal subjects (9 men, 2 women; 34 +/- 11 years of age). Following an ambulatory control evaluation, all subjects underwent 12 weeks of bed rest. An additional metabolic evaluation was performed after 12 days of reambulation. Bone mineral density declined at the spine (-2.9%, p = 0.092) and… CONTINUE READING
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