The effects of tryptophan depletion on cognitive and affective processing in healthy volunteers

@article{Murphy2002TheEO,
  title={The effects of tryptophan depletion on cognitive and affective processing in healthy volunteers},
  author={Fionnuala Murphy and Kent Smith and Philip J. Cowen and Trevor W. Robbins and Barbara J. Sahakian},
  journal={Psychopharmacology},
  year={2002},
  volume={163},
  pages={42-53}
}
Rationale. Cognitive impairment is a common feature of depressive illness. While accumulating evidence suggests that brain serotonin (5-HT) pathways play an important role in the neurobiology of depression, the extent to which altered 5-HT function is responsible for the associated changes in cognition and emotion remains unclear. Objective. The present study examined the effects of acute dietary depletion of tryptophan (TRP) on cognitive and affective processing in healthy volunteers and… CONTINUE READING
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Effect of tryptophan depletion on mood in male and female volunteers: a pilot study

KA Smith, EM Clifford, RA Hockney, DM Clark, PJ Cowen
Hum Psychopharmacol • 1997
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