The effects of traditional tonics on fatigue in mice differ from those of the antidepressant imipramine: a pharmacological and behavioral study.

@article{Tadano2000TheEO,
  title={The effects of traditional tonics on fatigue in mice differ from those of the antidepressant imipramine: a pharmacological and behavioral study.},
  author={Takeshi Tadano and Osamu Nakagawasai and Fukie Niijima and Koichi Tan-no and Kensuke Kisara},
  journal={The American journal of Chinese medicine},
  year={2000},
  volume={28 1},
  pages={97-104}
}
The present studies were undertaken to investigate the differences between the antidepressant drug, imipramine, and liquid nutritive and tonic drugs (NTDs) that consist of Ginseng radix, Epimedii herba, Holen and an additional eight to twelve crude drugs. After preloading forced swimming, the NTD (applied orally, 0.1 ml/10 g) significantly increased the duration time of swimming and decreased the duration time of immobility, while the administration of imipramine (5, 10 and 20 mg/kg, i.p… CONTINUE READING