The effects of total lymphocyte deficiency on the extent of atherosclerosis in apolipoprotein E-/- mice.

@article{Daugherty1997TheEO,
  title={The effects of total lymphocyte deficiency on the extent of atherosclerosis in apolipoprotein E-/- mice.},
  author={Alan Daugherty and Ellen Pur{\'e} and D Delfel-Butteiger and Shu-hsia Chen and John M. Leferovich and S E Roselaar and Daniel J. Rader},
  journal={The Journal of clinical investigation},
  year={1997},
  volume={100 6},
  pages={1575-80}
}
Activated T lymphocytes are present in human atherosclerotic lesions and autoantibodies to antigens within lesions have been detected in serum, but the roles of the cellular and humoral immune systems in atherogenesis have not been determined. The effect of total lymphocyte deficiency on atherogenesis was investigated by crossing apo E-deficient mice (which develop atherosclerosis resembling human disease) with mice deficient in RAG2 (which is required for normal B and T lymphocyte development… CONTINUE READING