The effects of tibolone on mood and libido

@article{Davis2002TheEO,
  title={The effects of tibolone on mood and libido},
  author={S. Davis},
  journal={Menopause},
  year={2002},
  volume={9},
  pages={162-170}
}
ObjectiveTo review published data pertaining to the effects of tibolone on sexual parameters, mood, and cognitive function in postmenopausal women. DesignA review of all relevant published, peer-reviewed studies. ResultsTibolone is a compound that can be selectively metabolized by individual tissues to its estrogenic, progestogenic, or androgenic metabolites and hence exhibits tissue-specific hormonal effects. Tibolone also lowers sex hormone binding globulin, thus increasing free estradiol and… Expand
Beneficial effect of tibolone on mood, cognition, well-being, and sexuality in menopausal women
TLDR
Tibolone seems to be effective on estrogen-withdrawal symptoms such as hot flushes, sweating, insomnia, headache, and vaginal dryness, with results generally comparable to the effects exerted by estrogen-based treatments, and the additional property of a progestogenic activity on the endometrium. Expand
Metabolism of exogenous sex steroids and effect on brain functions with a focus on tibolone
TLDR
Tibolone is an ideal compound for studying steroid levels and metabolism in brain in view of its structural differences from endogenous steroids and its extensive metabolism required to express its endocrine effects. Expand
Androgen replacement therapy in women.
TLDR
The preponderance of evidence from clinical trials supports the correlation of decreased endogenous androgen levels with symptoms and alleviation of many of the symptoms with the administration of T or, in some cases, DHEA. Expand
The effect of tibolone versus 17beta-estradiol on climacteric symptoms in women with surgical menopause: a randomized, cross-over study.
TLDR
It is suggested that tibolone may improve mood, libido and somatic symptoms in surgically menopausal women to a greater extent than estrogen therapy alone. Expand
Role of androgens, progestins and tibolone in the treatment of menopausal symptoms: a review of the clinical evidence
TLDR
The synthetic steroid tibolone is widely used in Europe and Australasia and effectively treats hot flushes and vaginal dryness and may improve libido more effectively than estrogen containing HT in some women. Expand
Tibolone: how does its mechanism of action translate into clinical effects.
The various biological mechanisms that could explain the wide variety of clinical effects seen with postmenopausal hormonal therapy (HT) are presented in this Maturitas supplement, and in particularExpand
Tibolone: clinical recommendations and practical guidelines. A report of the International Tibolone Consensus Group.
TLDR
Tibolone is a valuable treatment option for women with climacteric complaints and might be preferable to EPT in certain women who have not been hysterectomised, and has positive effects on sexual well-being and mood. Expand
Effect on sexual life – a comparison between tibolone and continuous combined conjugated equine estrogens and medroxyprogesterone acetate
TLDR
It is indicated that both tibolone and continuous combined CEE/MPA treatment were associated with significant improvements in sexual function in postmenopausal women, however, tIBolone treatment improved sexual function to a greater extent than continuous combined MPA. Expand
Effects of tibolone and raloxifene on health-related quality of life and sexual function.
TLDR
In older postmenopausal women, tibolone treatment showed a trend towards an improvement in quality of life and sexuality when compared to raloxifene. Expand
Loss of libido in postmenopausal women
TLDR
The aim of this paper is to review the different studies and modalities of therapy which were found to improve the sexual function in postmenopausal women. Expand
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Tibolone seems to offer a complete treatment of the climacteric complaints whilst avoiding some of the problems associated with classical hormone replacement therapy. Expand
Comparative effects of estrogens plus androgens and tibolone on bone, lipid pattern and sexuality in postmenopausal women.
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The combined regimen of androgens and ERT increased vertebral bone mass and enhance sexual activity in postmenopausal women equal to that of tibolone and to a greater extent than ERT alone; its effects on lipids, however, are clearly adverse. Expand
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There were significantly greater increases in vaginal blood flow with tibolone in response to erotic fantasy but not film, suggesting two possible pathways of female sexual response. Expand
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Effect on sexual life--a comparison between tibolone and a continuous estradiol-norethisterone acetate regimen.
TLDR
It is indicated that tibolone and E2/NETA -which both have an androgenic profile-affect several aspects of sexual life positively and the difference with respect to satisfaction with sexual enjoyment and frequency could be of clinical importance. Expand
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Differential effects on the androgen status of postmenopausal women treated with tibolone and continuous combined estradiol and norethindrone acetate replacement therapy.
TLDR
Tibolone decreased the levels of SHBG, and substantially increased free T and to a lesser extent increased DHEAS; this may reflect a modification of adrenal androgen production. Expand
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TLDR
Both tibolone and CEE/MPA were safe with respect to effects on the endometrium and both treatments induced changes in the plasma profiles of certain lipid and lipoprotein parameters, however, the overall clinical implications of these changes are unknown. Expand
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