The effects of theophylline and nifedipine on corticotropin‐stimulated cortisol secretion

  title={The effects of theophylline and nifedipine on corticotropin‐stimulated cortisol secretion},
  author={Michael T. Mcdermott and Thomas L. Walden and M Bornemann and Robert J Sjoberg and Fred D. Hofeldt and Gerald S. Kidd},
  journal={Clinical Pharmacology \& Therapeutics},
The adrenal cortisol response to corticotropin appears to involve both calcium and cyclic adenosine 3′,5′‐monophosphate (cAMP) as intracellular mediators. In 10 healthy male volunteers, the short‐term administration of theophylline, which affects both intracellular calcium and cAMP, lowered basal cortisol levels but augmented the in vivo cortisol response to short‐term corticotropin stimulation. Short‐term administration of nifedipine, a calcium channel antagonist, had no effect on basal or… 
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Calcium channel blockers impair the pituitary-adrenocortical responses to central adrenergic receptors stimulation.

It is indicated that verapamil and nifedipine interfere predominantly with calcium channels on the hypothalamic CRH secreting neurons and anterior pituitary corticotrops when inhibiting pitsuitary-adrenocortical activity stimulated by adrenergic receptor agonists.



Effect of theophylline on cortisol secretion.

The effect of long-term verapamil treatment on the secretion of cortisol and aldosterone in subjects with normal and high blood pressure.

  • I. Z̆ofková
  • Medicine, Biology
    Experimental and clinical endocrinology
  • 1985
Verapamil, 3-4 X 80 mg per day by the oral route, did not lead to significant changes of cortisol levels at rest nor after ACTH stimulation when assessed at the end of the first month of treatment in both groups, however, normotensive subjects with Raynaud's syndrome showed a decline of ACTH stimulated cortisolaemia during the 3rd month and 4th month.

In vitro effects of theophylline and aminogluthetimide upon basal and ACTH induced cAMP levels and steroid output by the normal human adrenal gland.

The findings indicate that both theophylline and aminogluthetimide produce effects upon the adrenal in addition to inhibition of phosphodiesterase and cholesterol side-chain cleavage, respectively, which may be helpful in understanding the interplay between a number of factors in the control of adrenal steroid biosynthesis and release.

Effect of nifedipine on blood pressure and adrenocortical responses to trophic stimuli in humans.

The data indicate that ald testosterone release in humans is calcium dependent, and that nifedipine decreases the sensitivity of the zona glomerulosa to angiotensin II, but has no effect on the aldosterone or cortisol responses to ACTH.

Effects of intravenous and oral verapamil upon pressor and adrenal steroidogenic responses in normal man.

Verapamil given either acutely or chronically impaired the action of pressor hormones by a nonspecific action on vascular smooth muscle and impaired to a moderate degree adrenal steroidogenesis to two trophic factors, suggesting that its adrenal effect is time dependent.

Effect of nifedipine on the adrenocortical and somatotrophic secretory reserve and TSH and thyroid hormone plasma levels.

The authors investigated the effect of one week's administration of therapeutic doses of the calcium antagonist nifedipine on the hormone homeostasis of clinically healthy subjects and ruled out possible adverse side-effects.

Effects of calcium and theophylline on ACTH- and dibutyryl cyclic AMP-stimulated steroidogenesis and glycolysis by intact mouse adrenal glands in vitro.

Theophylline inhibited the glycolytic action of ACTH, dibutyryl cyclic AMP and exogenous steroids, denoting that its effects are not confined to the inhibition of phosphodiesterase.

Nifedipine does not impair the hormonal responses to graded exercise in healthy subjects.

It was concluded that, apart from inducing significant changes in blood pressure, a single dose of nifedipine does not appear to suppress the counterregulatory hormonal responses to short-term physical activity in healthy men.

An Anomalous Effect of Theophylline on ACTH and Adenosine 3′,5′-Monophosphate Stimulation.∗

It is suggested that theophylline action in rat adrenals has two antagonistic components, potentiation of the steroidogenic action by protection of .3′,5′-AMP, and reduction of theabolic action by inhibition of protein synthesis.

Acute inhibition of corticosteroidogenesis by inhibitors of calmodulin action.

It is suggested that calmodulin may modulate the effect of ACTH on steroidogenesis at multiple sites, as shown by the finding that it inhibited cAMP-induced B production.