The effects of theophylline and nifedipine on corticotropin‐stimulated cortisol secretion

@article{Mcdermott1990TheEO,
  title={The effects of theophylline and nifedipine on corticotropin‐stimulated cortisol secretion},
  author={Michael T. Mcdermott and Thomas L. Walden and M Bornemann and Robert J Sjoberg and Fred D. Hofeldt and Gerald S. Kidd},
  journal={Clinical Pharmacology \& Therapeutics},
  year={1990},
  volume={47}
}
The adrenal cortisol response to corticotropin appears to involve both calcium and cyclic adenosine 3′,5′‐monophosphate (cAMP) as intracellular mediators. In 10 healthy male volunteers, the short‐term administration of theophylline, which affects both intracellular calcium and cAMP, lowered basal cortisol levels but augmented the in vivo cortisol response to short‐term corticotropin stimulation. Short‐term administration of nifedipine, a calcium channel antagonist, had no effect on basal or… 
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Calcium channel blockers impair the pituitary-adrenocortical responses to central adrenergic receptors stimulation.

It is indicated that verapamil and nifedipine interfere predominantly with calcium channels on the hypothalamic CRH secreting neurons and anterior pituitary corticotrops when inhibiting pitsuitary-adrenocortical activity stimulated by adrenergic receptor agonists.

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  • I. Z̆ofková
  • Medicine, Biology
    Experimental and clinical endocrinology
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