The effects of the inhibition of inducible nitric oxide synthase on angiogenesis of epithelial ovarian cancer.

@article{Malone2006TheEO,
  title={The effects of the inhibition of inducible nitric oxide synthase on angiogenesis of epithelial ovarian cancer.},
  author={John M. Malone and Ghassan M. Saed and Michael Peter Diamond and Robert J. Sokol and Adnan R. Munkarah},
  journal={American journal of obstetrics and gynecology},
  year={2006},
  volume={194 4},
  pages={1110-6; discussion 1116-8}
}
OBJECTIVE The release of nitric oxide by tumor cells, through the stimulation of inducible nitric oxide synthase expression, may play a critical role in ovarian cancer progression. In this study we have sought to determine the effects of inhibiting inducible nitric oxide synthase on angiogenesis that was induced by 2 ovarian cancer cell lines, SKOV and MDAH2774. STUDY DESIGN Real-time polymerase chain reaction and enzyme-linked immunosorbent assay techniques were used to determine the… CONTINUE READING