The effects of the TRPV1 receptor antagonist SB-705498 on trigeminovascular sensitisation and neurotransmission

@article{Lambert2009TheEO,
  title={The effects of the TRPV1 receptor antagonist SB-705498 on trigeminovascular sensitisation and neurotransmission},
  author={G. A. Lambert and John B. Davis and Jonathan M Appleby and Boris Andreyevich Chizh and Karen Lisa Hoskin and Alessandro Stefano Zagami},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={2009},
  volume={380},
  pages={311-325}
}
This report examines the effect of the transient receptor potential vanilloid 1 receptor antagonist SB-705498 on neurotransmission and inflammation-induced sensitisation in the trigeminovascular sensory system. A single-neuron electrophysiological animal model for neurovascular head pain was used to evaluate dural and facial noxious inputs and the effects of SB-705498 administered by intravenous (i.v.) injection. Electrical and mechanical stimulation of the dura mater and the facial skin… CONTINUE READING

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