The effects of the Roche AMPLICOR HIV-1 MONITOR UltraSensitive Test versions 1.0 and 1.5 viral load assays and plasma collection tube type on determination of response to antiretroviral therapy and the inappropriateness of cross-study comparisons.

@article{Giordano2006TheEO,
  title={The effects of the Roche AMPLICOR HIV-1 MONITOR UltraSensitive Test versions 1.0 and 1.5 viral load assays and plasma collection tube type on determination of response to antiretroviral therapy and the inappropriateness of cross-study comparisons.},
  author={Michael Giordano and Thomas D Kelleher and R. J. Colonno and Adriano Lazzarin and Kathleen M Squires},
  journal={Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology},
  year={2006},
  volume={35 4},
  pages={420-5}
}
BACKGROUND Because there are limited head-to-head data comparing antiretroviral combinations, physicians are tempted to rely on cross-trial comparisons to evaluate the relative efficacy of HIV drugs. However, a variety of factors can confound these comparisons, resulting in misleading or invalid conclusions. OBJECTIVES To compare and evaluate the use of: (i) versions 1.0 and 1.5 of the Roche AMPLICOR HIV-1 MONITOR UltraSensitive assay, and (ii) ethylenediaminetetraacetic acid (EDTA) and… CONTINUE READING

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