The effects of the COMT inhibitor entacapone on haemodynamics and peripheral catecholamine metabolism during exercise.

@article{Sundberg1993TheEO,
  title={The effects of the COMT inhibitor entacapone on haemodynamics and peripheral catecholamine metabolism during exercise.},
  author={Stig Sundberg and Mika Scheinin and A. Illi and Juha Akkila and Ariel Gordin and T Ker{\"a}nen},
  journal={British journal of clinical pharmacology},
  year={1993},
  volume={36 5},
  pages={451-6}
}
1. Catechol-O-methyltransferase (COMT) inhibition might be assumed to potentiate the effects of circulating catecholamines, particularly under conditions of enhanced catecholamine release. 2. The purpose of the present study was to establish whether the novel COMT inhibitor, entacapone, changes haemodynamic responses and catecholamine metabolism during exercise. 3. Entacapone was given orally to 12 healthy male subjects (age 23-30 years) in increasing single doses from 0 mg (control day) to 200… CONTINUE READING