The effects of the 5-HT1A agonist flesinoxan, in three paradigms for assessing antidepressant potential in the rat

@article{Cryan1997TheEO,
  title={The effects of the 5-HT1A agonist flesinoxan, in three paradigms for assessing antidepressant potential in the rat},
  author={John F. Cryan and Anna M Redmond and John P Kelly and Brian E. Leonard},
  journal={European Neuropsychopharmacology},
  year={1997},
  volume={7},
  pages={109-114}
}

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It would appear that flesinoxan should be a useful compound in the clinical management of anxiety after being examined under a procedure that has proved to be a reliable and sensitive method for detecting novel anxiolytic drugs believed to produce their effects at the 5-HT 1A receptor subtype.

Some behavioural and neurochemical effects of ipsapirone in two rodent models of depression

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Pilot study of flesinoxan, a 5‐HT1A agonist, in major depression: Effects on sleep REM latency and body temperature

Flesinoxan is a highly potent and selective 5‐HT1A full agonist, active in several models of depression. In this pilot open study, flesinoxan (4 mg/d) was administered orally for 4 weeks in 16 major

An open study of oral flesinoxan, a 5‐HT1A receptor agonist, in treatment‐resistant depression

The observations suggested that flesinoxan is an antidepressant agent and that it may be of particular value in some difficult, treatment-resistant depressions.

Further Characterization of the Discriminative Stimulus Induced by Flesinoxan

The present results are in favour of a 5-HT1A mechanism for the discriminative stimulus of flesinoxan and consistent with the results of previous drug discrimination studies with fles inoxan.