OBJECTIVE To investigate the effects of Tablet Tongmaijiangzhi on hyperlipidemia and nitric oxide of patients with non-insulin-dependent diabetes mellitus. METHOD 65 patients were randomly divided into Tablet Tongmaijiangzhi(TTMJZ) group(33 patients) and Zocor group(32 patients), treated with TTMJZ 4 tab, tid. and Zocor 5 mg, qd. respectively for 8 weeks. RESULT Serum levels of TC, LDL, ApoB were markedly decreased in both groups after treatments (P < 0.01). Non-significant difference was found between these two groups (P > 0.05). But after treatment the serum levels of TG were decreased and the serum levels of HDL, ApoA1 were increased significantly in TTMJZ group than in Zocor group (P < 0.05). Furthermore, the serum level of nitric oxide(NO) was increased and the blood viscosity was decreased significantly after treated with TTMJZ (P < 0.05 or P < 0.01). CONCLUSION Tablet Tongmaijiangzhi has the advantage of Zocor in lipids regulating effects on patients with non-insulin-dependent diabetes mellitus and hyperlipidemia. TTMJZ can also decrease blood viscosity and increase NO to protect vascular endothelium.