The effects of sulfonylurea glyburide on superoxide dismutase, catalase, and glutathione peroxidase activities in the brain tissue of streptozotocin-induced diabetic rat.

@article{Nazaroglu2009TheEO,
  title={The effects of sulfonylurea glyburide on superoxide dismutase, catalase, and glutathione peroxidase activities in the brain tissue of streptozotocin-induced diabetic rat.},
  author={N. Kemal Nazaroglu and Aylin Sepici-Dinçel and Nilgun Altan},
  journal={Journal of diabetes and its complications},
  year={2009},
  volume={23 3},
  pages={209-13}
}
OBJECTIVES A member of the second-generation sulfonylureas, glyburide (GLY; glibenclamide) provides an effective therapy for patients with type 2 diabetes. It stimulates pancreatic insulin secretion, suggesting that it is effective in the treatment of type 2 diabetes primarily by elevating the circulating insulin levels. However, experimental evidences have indicated that sulfonylureas have also had an extrapancreatic effect, which may directly contribute toward maintaining blood glucose… CONTINUE READING
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