The effects of storage and sterilization on de-cellularized and re-cellularized whole lung.

@article{Bonenfant2013TheEO,
  title={The effects of storage and sterilization on de-cellularized and re-cellularized whole lung.},
  author={Nicholas R. Bonenfant and Dino Sokocevic and Darcy E Wagner and Zachary D. Borg and Melissa J. Lathrop and Ying Wai Lam and Bin Deng and Michael J Desarno and Taka Ashikaga and Roberto Loi and Daniel Weiss},
  journal={Biomaterials},
  year={2013},
  volume={34 13},
  pages={3231-45}
}
Despite growing interest on the potential use of de-cellularized whole lungs as 3-dimensional scaffolds for ex vivo lung tissue generation, optimal processing including sterilization and storage conditions, are not well defined. Further, it is unclear whether lungs need to be obtained immediately or may be usable even if harvested several days post-mortem, a situation mimicking potential procurement of human lungs from autopsy. We therefore assessed effects of delayed necropsy, prolonged… CONTINUE READING

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