The effects of statins on the mevalonic acid pathway in recombinant yeast strains expressing human HMG-CoA reductase

@inproceedings{Maciejak2013TheEO,
  title={The effects of statins on the mevalonic acid pathway in recombinant yeast strains expressing human HMG-CoA reductase},
  author={Agata Maciejak and Agata Leszczynska and Ilona Warchol and Monika G{\'o}ra and Joanna A Kamińska and Danuta Plochocka and Monika Wysocka-Kapcińska and Dorota Tulacz and Joanna Siedlecka and Ewa Swiezewska and Maciej Sojka and Witold Danikiewicz and Norbert Odolczyk and Anna Szkopińska and Grażyna Sygitowicz and Beata Burzynska},
  booktitle={BMC biotechnology},
  year={2013}
}
BACKGROUND The yeast Saccharomyces cerevisiae can be a useful model for studying cellular mechanisms related to sterol synthesis in humans due to the high similarity of the mevalonate pathway between these organisms. This metabolic pathway plays a key role in multiple cellular processes by synthesizing sterol and nonsterol isoprenoids. Statins are well-known inhibitors of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR), the key enzyme of the cholesterol synthesis pathway. However, the effects… CONTINUE READING
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