The effects of some benzoic acid derivatives on polymorphonuclear leukocyte accumulation in vivo.

  title={The effects of some benzoic acid derivatives on polymorphonuclear leukocyte accumulation in vivo.},
  author={J. J. Killackey and B. A. Killackey and Richard B. Philp},
  journal={International journal of immunopharmacology},
  volume={7 5},
Previous studies, aimed at establishing a relationship between the inhibition of prostaglandin (PG) biosynthesis and the suppression of carrageenin-induced rat paw edema, indicated that, in a series of acetylsalicylic acid (ASA)-like compounds, there is not a good correlation between ability to inhibit platelet PG biosynthesis and anti-inflammatory activity. Some of the compounds tested had good anti-edema properties compared to ASA, but did not inhibit platelet lysate conversion of 14C… Expand
Cyclic nucleotide phosphodiesterase inhibition by a benzoic acid derivative
It is proposed that the potent anti-inflammatory effects of 3-MP, which differ from those of ASA, are mediated through the inhibition of the cyclic nucleotide PDE system. Expand
Liquid-phase catalytic oxidation of p-acyl-substituted toluenes with oxygen
A method based on the liquid-phase oxidation of p-acyl-substituted toluenes has been developed for the synthesis of p-acyl-substituted benzoic acids. It is possible s to recycle the unreactedExpand


Studies on the Mode of Action of Non-Steroidal Anti-Inflammatory Agents
The recent proposal by Vane and his associates at the Royal College of Surgeons in London (Vane, 1971; Smith and Willis, 1971; Ferreira et al, 1971) that the antiinflammatory activity of indomethacinExpand
Structure-activity studies of aspirin and related compounds on platelet aggregation, arachidonic acid metabolism in platelets and artery, and arterial prostacyclin activity.
A cyclical derivative, 3-methylphthalide (3-MP), inhibited both platelet function and PGI2 synthesis although it did not inhibit cyclo-oxygenase activity, suggesting a novel mechanism of action. Expand
Leukotriene B, a potent chemokinetic and aggregating substance released from polymorphonuclear leukocytes
The chemokinetic and aggregating activities released from rat and human PMNs exposed to ionophore A23187 are not due to the release of mono-HETEs but to that of 5,12-di- HETE (leukotriene B), which is active over the concentration range 10 pg ml−1 to 5 ng ml-1. Expand
Inhibition by prostaglandins of leukotriene B4 release from activated neutrophils.
The fMet-Leu-Phe-induced adherence of PMN to endothelial cells and inhibition of this phenomenon by PGs may now be explained by PG-mediated inhibition of LTB4 formation. Expand
The human PMN leukocyte chemotactic activity of complex hydroxy-eicosatetraenoic acids (HETEs).
The lipoxygenation of arachidonic acid in basophils, mastocytoma cells, and other leukocytes generates the unstable intermediate 5-hydroperoxy-eicostaetraenoic acid, which is converted in part to a series of complex HETEs with additional polar substituents and 3 conjugated double bonds. Expand
The effects of some salicylate analogues on human blood platelets. 1. Structure activity relationships and the inhibition of platelet aggregation.
The results indicate that structural specificity is important for the aggregation inhibiting activity of aspirin, but do not support the contention that such inhibition is dependent upon the availability of an acetyl radical. Expand
The release of leukotriene B4 during experimental inflammation.
The PMN count in the sponges and the concentrations of both LTB4 and TXB2, but not PGE2, were significantly reduced by prior treatment of the animals with colchicine, which suggests that PMN are the major source of L TB4 andTXB2 in the inflammatory exudate whereas P GE2 is produced in significant amounts by other tissues. Expand
Potentiation of the Anti-Inflammatory and Analgesic Activity of Aspirin by Caffeine in the Rat
Summary Caffeine has been found to potentiate the acute anti-inflammatory activity of aspirin, indomethacin, and phenylbuta-zone, but not the activity of sodium salicy-late or hydrocortisone, in theExpand
Cyclo-oxygenase products in carrageenin-induced inflammation
Abstract Prostaglandin (PG) E2, thromboxane (TX) B2 and the stable breakdown product of prostacyclin, 6-oxo-PGF1α are present in carrageenin-induced inflammatory exudates. Carrageenin-impregnatedExpand
The source of thromboxane and prostaglandins in experimental inflammation
The results indicate that platelets are the source of TXB2 in clotting blood but do not contribute to cyclo‐oxygenase activity in experimental inflammation and suggest that migrating leukocytes are the major source of thromboxane and to a lesser degree prostaglandins in acute 6 h inflammatory exudates. Expand