The effects of some α-adrenoceptor antagonists on the responses of the canine saphenous vein to B-HT 933, UK-14304 and methoxamine

The benzoquinolizines Wy 25309, Wy 26703 and Wy 27127, previously reported as potent antagonists at presynaptic α2-adrenoceptors were also potent antagonists of B-HT 933 in isolated saphenous veins of the dog confirming their activity at post synaptic α2-adrenoceptors. Yohimbine was a more potent antagonist of B-HT 933 in isolated saphenous vein than were… CONTINUE READING