The effects of sodium, hydrogen and magnesium ions on mitochondrial calcium sequestration in adult rat ventricular myocytes.

@article{Fry1984TheEO,
  title={The effects of sodium, hydrogen and magnesium ions on mitochondrial calcium sequestration in adult rat ventricular myocytes.},
  author={Christopher Henry Fry and Trevor Powell and V. W. Twist and Jeremy P T Ward},
  journal={Proceedings of the Royal Society of London. Series B, Biological sciences},
  year={1984},
  volume={223 1231},
  pages={239-54}
}
The effect of Na+, H+ and Mg2+ ions on net calcium exchange induced in digitonin-treated myocytes has been investigated. Raising the [Na] from 1.4 to 31.4 mM revealed a sodium-sensitive fraction of net calcium exchange with a K1/2 for Na+ ions of 12 mM, alongside the respiration-dependent accumulation of calcium. An acidosis, but not an alkalosis, was found to depress both of these processes. Mg2+ ions exerted an effect solely on the respiration-dependent calcium sequestration. A simple semi… CONTINUE READING