The effects of sitagliptin on gastric emptying in healthy humans - a randomised, controlled study.

@article{Stevens2012TheEO,
  title={The effects of sitagliptin on gastric emptying in healthy humans - a randomised, controlled study.},
  author={Julie Eva Stevens and Michael Horowitz and Carolyn F Deacon and Michael A Nauck and Christopher K Rayner and Karen L Jones},
  journal={Alimentary pharmacology & therapeutics},
  year={2012},
  volume={36 4},
  pages={379-90}
}
BACKGROUND The rate of gastric emptying (GE) and subsequent release of the incretin hormones, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) are critical determinants of postprandial glycaemia in health and type 2 diabetes. Slowing of GE may be the dominant mechanism by which exogenous GLP-1, and some GLP-1 analogues, improve postprandial glycaemia. AIM To determine the effect of sitagliptin on GE in healthy subjects, and the relationships between GE with… CONTINUE READING
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The effect of DPP-4 inhibition with sitagliptin on incretin secretion and on fasting and postprandial glucose turnover in subjects with impaired fasting glucose

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