The effects of single dose oral hydralazine on blood flow through human lung tumours.

@article{Rowell1990TheEO,
  title={The effects of single dose oral hydralazine on blood flow through human lung tumours.},
  author={Nicholas P Rowell and M. A. Flower and V Ralph McCready and Bernadette Cronin and Alan H. Horwich},
  journal={Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology},
  year={1990},
  volume={18 4},
  pages={283-92}
}
Hydralazine has been shown to reduce tumour blood flow and to potentiate the cytotoxicity of melphalan and bioreductive agents in mice. In order to determine whether such a strategy might have clinical potential, a study was undertaken to investigate the effects of hydralazine on blood flow through human tumours. Twenty-two patients with carcinoma of the bronchus received a single oral dose of hydralazine in the range 25 to 150 mg (0.37-2.86 mg/kg) according to age and acetylator status. Tumour… CONTINUE READING

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