The effects of single L-amino acid substitutions on the lethal potencies of the microcystins.

@article{Stoner1989TheEO,
  title={The effects of single L-amino acid substitutions on the lethal potencies of the microcystins.},
  author={Richard D. Stoner and W. H. Adams and Daniel N. Slatkin and H. W. Siegelman},
  journal={Toxicon : official journal of the International Society on Toxinology},
  year={1989},
  volume={27 7},
  pages={825-8}
}
Microcystin-LR and -LA are more toxic than microcystin-LY and -RR in adult mice. They induce different degrees of thrombocytopenia and leukopenia, and the lethalities of their binary and ternary mixtures are addictive. Postnatal mice are resistant to doses of microcystin-LR that are lethal to adults but they are susceptible to higher doses. Substitution of a single L-amino acid for another in a microcystin markedly affects the dosimetric potency, but not the pathophysiology of its toxicity. 

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