The effects of silymarin on the attachment and viability of primary cultures of rat hepatocytes.

Abstract

The effects of the hepatoprotective compound silymarin on hepatocytes in primary culture were studied. Exposure of cells in primary culture (both conventional cells and perivenous or periportal cells isolated by the digitonin-collagenase perfusion technique) to high concentrations of silymarin surprisingly demonstrated that silymarin per se was cytotoxic… (More)

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@article{SainzPardo1994TheEO, title={The effects of silymarin on the attachment and viability of primary cultures of rat hepatocytes.}, author={Luis Sainz-Pardo and Irene Anundi and Mar{\'i}a Del Prado M{\'i}guez and Kai O. Lindros}, journal={Toxicology in vitro : an international journal published in association with BIBRA}, year={1994}, volume={8 4}, pages={577-9} }