The effects of short-term genistein intervention on prostate biomarker expression in patients with localised prostate cancer before radical prostatectomy

@article{Lazarevic2012TheEO,
  title={The effects of short-term genistein intervention on prostate biomarker expression in patients with localised prostate cancer before radical prostatectomy},
  author={Bato Lazarevic and Clara Hammarstr{\"o}m and Jin Yang and H{\aa}kon Ramberg and Lien My Diep and Steinar Johan Karlsen and Omer Kucuk and Fahri Saatcioglu and Kristin Austlid Tasken and Aud Svindland},
  journal={British Journal of Nutrition},
  year={2012},
  volume={108},
  pages={2138 - 2147}
}
Nutritionally relevant levels of genistein, the predominant isoflavone in soyabean associated with lower risk of prostate cancer (PCa), may modulate the expression of prostate tissue biomarkers associated with cancer prediction and progression. A phase 2 placebo-controlled, randomised, double-blind clinical trial was conducted in forty-seven Norwegian patients before prostatectomy. Intervention was 30 mg genistein or placebo capsules daily for 3–6 weeks. Luminal cells from malignant and benign… 
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References

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TLDR
Genistein at a dose that can be easily obtained from a diet rich in soy reduced the level of serum PSA in patients with localized CaP, without any effects on hormones, and had a beneficial effect on blood cholesterol.
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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