The effects of severe maternal diabetes on glucose transport in the fetal rat.

@article{Atkins1994TheEO,
  title={The effects of severe maternal diabetes on glucose transport in the fetal rat.},
  author={Veronica Atkins and Annette S. Flozak and Edward S. Ogata and Rebecca A. Simmons},
  journal={Endocrinology},
  year={1994},
  volume={135 1},
  pages={409-15}
}
We mimicked the condition of severe maternal diabetes by administering high doses of streptozotocin (STZ) to the pregnant rat to determine the effects of increased glucose availability on fetal glucose transport and to assess whether a relationship might exist between glucose transport and altered fetal growth. Fetuses of STZ-treated pregnant rats were growth retarded (3.86 +/- 0.13 vs. 5.29 +/- 0.06 g), hyperglycemic (30.0 +/- 1.0 vs. 5.5 +/- 0.5 mM/liter), and hyperinsulinemic (1263.8 +/- 138… CONTINUE READING