The effects of sevelamer hydrochloride and calcium carbonate on kidney calcification in uremic rats.

@article{Cozzolino2002TheEO,
  title={The effects of sevelamer hydrochloride and calcium carbonate on kidney calcification in uremic rats.},
  author={Mario Gennaro Cozzolino and Adriana S. Dusso and Helen Liapis and Jane L. Finch and Yan Lu and Steven K. Burke and Eduardo M Slatopolsky},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2002},
  volume={13 9},
  pages={2299-308}
}
The control of serum phosphorus (P) and calcium-phosphate (Ca x P) product is critical to the prevention of ectopic calcification in chronic renal failure (CRF). Whereas calcium (Ca) salts, the most commonly used phosphate binders, markedly increase serum Ca and positive Ca balance, the new calcium- and aluminum-free phosphate binder, sevelamer hydrochloride (RenaGel), reduces serum P without altering serum Ca in hemodialysis patients. Using an experimental model of CRF, these studies compare… CONTINUE READING
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p21 and TGFalpha mediate parathyroid growth arrest by vitamin D and high calcium

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