The effects of scopolamine on sleep and mood in depressed patients with a history of alcoholism and a normal comparison group.

@article{Gillin1991TheEO,
  title={The effects of scopolamine on sleep and mood in depressed patients with a history of alcoholism and a normal comparison group.},
  author={J. Christian Gillin and Laurent Sutton and Caroline Ruiz and Daniel Darko and Shahrokh Golshan and Samuel C. Risch and David S. Janowsky},
  journal={Biological psychiatry},
  year={1991},
  volume={30 2},
  pages={157-69}
}
In order to determine the effect of an anticholinergic agent on mood and sleep, scopolamine (0.4 mg IM) was administered before bedtime for three consecutive nights to 10 depressed patients (8 with a history of alcohol abuse) and 10 normal comparison subjects. The patients had a small, statistically significant antidepressant response on the second morning of treatment. Scopolamine inhibited rapid eye movement (REM) sleep and prolonged REM latency equally in depressed patients and the normal… CONTINUE READING

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