The effects of saquinavir on imatinib-resistant chronic myelogenous leukemia cell lines.

Abstract

We evaluated the effect of the human immunodeficiency virus (HIV) protease inhibitor saquinavir on the imatinib-sensitive and imatinib-resistant chronic myelogenous leukemia cell lines. Saquinavir, which is also a proteasome blocker, showed dose- and time-related anti-proliferative activity, particularly on the imatinib-resistant lines and a pro-apoptotic… (More)

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@article{Timeus2006TheEO, title={The effects of saquinavir on imatinib-resistant chronic myelogenous leukemia cell lines.}, author={Fabio Timeus and Nicoletta Crescenzio and Emanuela Ricotti and Alessandra Doria and Daniele Bertin and Giuseppe Saglio and Pier Angelo Tovo}, journal={Haematologica}, year={2006}, volume={91 5}, pages={711-2} }