The effects of salicylate on the rectal absorption of phenylalanine and some peptides, and the effects of these peptides on the rectal absorption of cefoxitin and cefmetazole.

@article{Nishihata1984TheEO,
  title={The effects of salicylate on the rectal absorption of phenylalanine and some peptides, and the effects of these peptides on the rectal absorption of cefoxitin and cefmetazole.},
  author={Toshiaki Nishihata and Ching Sheng Lee and Masanobu Yamamoto and Joseph Howard Rytting and Toshihiro Higuchi},
  journal={Journal of pharmaceutical sciences},
  year={1984},
  volume={73 9},
  pages={
          1326-8
        }
}
  • Toshiaki Nishihata, Ching Sheng Lee, +2 authors Toshihiro Higuchi
  • Published in
    Journal of pharmaceutical…
    1984
  • Chemistry, Medicine
  • The disappearance of phenylalanine and phenylalanylglycine from a perfusate circulated across rat rectal tissue was enhanced significantly in the presence of salicylate or 5-methoxysalicylate at pH 4.5, 7.4, and 8.5. The disappearance of di-, tri-, and tetraphenylalanine from a perfusate at pH 7.4, although facilitated by the presence of salicylate and 5-methoxysalicylate, was also fairly substantial when no adjuvant was present. These peptide analogues of phenylalanine also enhanced the rectal… CONTINUE READING

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