The effects of repeated doses of temazepam and nitrazepam on several measures of human performance

  title={The effects of repeated doses of temazepam and nitrazepam on several measures of human performance},
  author={A N Griffiths and Gioacchino Tedeschi and Alan Richens},
  journal={Acta Psychiatrica Scandinavica},
ABSTRACT The effects of six nightly doses of temazepam (20 mg), nitrazepam (10 mg) and placebo on saccadic eye movements, critical flicker fusion threshold, choice reaction time and mood were studied in eight volunteers. Performance was measured on nights 1 and 6 of each treatment. Nitrazepam produced a residual performance impairment on night 1 that disappeared by night 6, despite higher serum concentrations of the drug on the sixth night of treatment. Temazepam, with a shorter elimination… 

The effects of temazepam and ethanol on human psychomotor performance

The performance on the tracking, divided attention, and PAB reaction time tasks used in this study was impaired by a combination of Tmazepam and ethanol in doses which may not cause impairment when each is given alone.

Pharmacokinetics of temazepam after day-time and night-time oral administration

It is concluded that a chronopharmacokinetic effect was seen for temazepam; however it is unlikely to be of any clinical significance.

The use of microcomputer-based psychomotor tests for the evaluation of benzodiazepine effects on human performance: a review with emphasis on temazepam.

The benzodiazepines as a class of drugs impair both cognitive and motor performance, and no single psychomotor task adequately simulates complex daily tasks such as automobile driving.

Effects of central nervous system depressant drug overdose on cognitive functions and driving

Converging evidence from the neuropsychological assessment and epidemiological approach indicates that CNS-D overdose has deleterious effects on driving.

Eye Movements as Biomarkers to Evaluate Pharmacological Effects on Brain Systems

This chapter introduces the concept of pharmacological model systems and will explain how eye movements may be used in such designs and the treatment effects of antipsychotics in schizophrenia, stimulant in ADHD, and stimulants in Parkinson’s disease.

Evaluation of saccahc eye movements as an objective test of recovery from anaesthesia

The aim of the present study was to validate saccades as a recovery index in relation to frequently referred subjective and psychometric tests.

Critical Knowledge Gaps Concerning Pharmacological Fatigue Countermeasures for Sustained and Continuous Aviation Operations

This type of review is a necessary step in developing an operationally based, safe-to-fly pharmacological doctrine that extends mission performance without introducing unwanted side effects.


A new HPLC method was developed for selective and simultaneous determination of of Teamazepam . The developed method is also applicable for the related substances determination in bulk dru gs. The



The effect of repeated doses of temazepam and nitrazepam on human psychomotor performance.

It is concluded that tolerance developed to the sedative action of nitrazepam over the 6 night period of the study and no evidence of tolerance was seen with temazepam.

Effects of hypnotic and sleep-inducing drugs on objective assessments of human psychomotor performance and subjective appraisals of sleep and early morning behaviour.

  • I. Hindmarch
  • Psychology, Medicine
    British journal of clinical pharmacology
  • 1979
1 An acute dose comparison against placebo of the effects of nitrazepam 5 mg and temazepam 15 and 30 mg on measures of arousal and performance and on subjective assessment of sleep was carried out in

The relationship between peak velocity of saccadic eye movements and serum benzodiazepine concentration.

A clear relationship between serum benzodiazepine concentration and its effect on a convenient measure of brainstem reticular formation function is demonstrated and is demonstrated in a double-blind randomized fashion.

Effect of a metabolite of diazepam, 3-hydroxydiazepam (temazepam), on sleep in man.

The subjects, as a group, reported improved sleep, but subjective assessments of well-being were not altered, and correlations were calculated for sleep measures and subjective assessments.

A sub-chronic study of the subjective quality of sleep and psychological measures of performance on the morning following night time medication with temazepam.

A clear dose-response relationship was seen in the subjective and objective measurements with the three doses used, and a rebound phenomenon was seen only at the high dose levels in two subjective measures, viz. getting to sleep and behaviour following waking.

Benzodiazepine hypnotics remain effective for 24 weeks.

It is concluded that benzodiazepines remain effective for at least 24 weeks but that a period of disturbed sleep may be expected after withdrawal.

Nitrazepam: lastingly effective but trouble on withdrawal.

Slow-wave sleep was reduced by nitrazepam, but the accompanying secretion of growth hormone was not impaired, and sleep was longer and less broken on the drug and no tolerance was obvious after two months' use.

Pharmacokinetics of the hypnotic benzodiazepine, temazepam.

To determine the absorption and elimination kinetics of temazepam from Normison® soft gelatin capsules, six healthy male volunteer subjects between 20 and 30 years of age and free of other medications for at least 1 week before the trial received 20 mg orally with a glass of water and on an empty stomach.

Saccadic eye movement analysis as a measure of drug effects on human psychomotor performance.

A suite of programmes have been developed to allow the generation, collection and analysis of saccadic eye movements using a CBM 3032, 8032 or BBC B microcomputer, which allows almost continuous sampling and rapid analysis of movements.

A Specific, Rapid and Sensitive Method for Gas-Chromatographic Determination of Methyloxazepam in Small Samples of Blood

Abstract A simple and sensitive gas-chromatographic method for the determination of methyloxazepam in small samples of blood or plasma is described. After ethereal extraction the methyloxazepam was