The effects of repeated doses of temazepam and nitrazepam on several measures of human performance

@article{Griffiths1986TheEO,
  title={The effects of repeated doses of temazepam and nitrazepam on several measures of human performance},
  author={A N Griffiths and Gioacchino Tedeschi and Alan Richens},
  journal={Acta Psychiatrica Scandinavica},
  year={1986},
  volume={74}
}
ABSTRACT The effects of six nightly doses of temazepam (20 mg), nitrazepam (10 mg) and placebo on saccadic eye movements, critical flicker fusion threshold, choice reaction time and mood were studied in eight volunteers. Performance was measured on nights 1 and 6 of each treatment. Nitrazepam produced a residual performance impairment on night 1 that disappeared by night 6, despite higher serum concentrations of the drug on the sixth night of treatment. Temazepam, with a shorter elimination… 
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References

SHOWING 1-10 OF 20 REFERENCES
The effect of repeated doses of temazepam and nitrazepam on human psychomotor performance.
TLDR
It is concluded that tolerance developed to the sedative action of nitrazepam over the 6 night period of the study and no evidence of tolerance was seen with temazepam.
Effects of hypnotic and sleep-inducing drugs on objective assessments of human psychomotor performance and subjective appraisals of sleep and early morning behaviour.
  • I. Hindmarch
  • Psychology, Medicine
    British journal of clinical pharmacology
  • 1979
1 An acute dose comparison against placebo of the effects of nitrazepam 5 mg and temazepam 15 and 30 mg on measures of arousal and performance and on subjective assessment of sleep was carried out in
The relationship between peak velocity of saccadic eye movements and serum benzodiazepine concentration.
TLDR
A clear relationship between serum benzodiazepine concentration and its effect on a convenient measure of brainstem reticular formation function is demonstrated and is demonstrated in a double-blind randomized fashion.
Effect of a metabolite of diazepam, 3-hydroxydiazepam (temazepam), on sleep in man.
TLDR
The subjects, as a group, reported improved sleep, but subjective assessments of well-being were not altered, and correlations were calculated for sleep measures and subjective assessments.
A sub-chronic study of the subjective quality of sleep and psychological measures of performance on the morning following night time medication with temazepam.
TLDR
A clear dose-response relationship was seen in the subjective and objective measurements with the three doses used, and a rebound phenomenon was seen only at the high dose levels in two subjective measures, viz. getting to sleep and behaviour following waking.
Benzodiazepine hypnotics remain effective for 24 weeks.
TLDR
It is concluded that benzodiazepines remain effective for at least 24 weeks but that a period of disturbed sleep may be expected after withdrawal.
Nitrazepam: lastingly effective but trouble on withdrawal.
TLDR
Slow-wave sleep was reduced by nitrazepam, but the accompanying secretion of growth hormone was not impaired, and sleep was longer and less broken on the drug and no tolerance was obvious after two months' use.
Pharmacokinetics of the hypnotic benzodiazepine, temazepam.
TLDR
To determine the absorption and elimination kinetics of temazepam from Normison® soft gelatin capsules, six healthy male volunteer subjects between 20 and 30 years of age and free of other medications for at least 1 week before the trial received 20 mg orally with a glass of water and on an empty stomach.
Saccadic eye movement analysis as a measure of drug effects on human psychomotor performance.
TLDR
A suite of programmes have been developed to allow the generation, collection and analysis of saccadic eye movements using a CBM 3032, 8032 or BBC B microcomputer, which allows almost continuous sampling and rapid analysis of movements.
...
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