The effects of repeated cycles of weight loss and regain in rats

  title={The effects of repeated cycles of weight loss and regain in rats},
  author={Kelly D. Brownell and M. R. C. Greenwood and Eliot Stellar and E. Eileen Shrager},
  journal={Physiology \& Behavior},

Figures and Tables from this paper

Effects of Multiple Cycles of Weight Loss and Regain on the Body-Weight Regulatory System in Rats.
Repeated weight-loss cycles exerted positive effects, durably lowering defended levels of body adiposity and improving glucose tolerance in rats.
Effects of repeated weight loss and regain on body composition in obese rats.
Repeated cycles of weight loss and regain do not produce increased body fatness or decreased rate of weight Loss in ovariectomized rats.
Effects of cycles of food restriction followed by ad libitum refeeding on body composition and energy expenditure in obese rats.
It is concluded that the practice of successive restriction and refeeding did not result in resistance to weight loss, but rather in a defect in the utilization of energy intake, facilitating the development of obesity.
Short-term weight cycling in aging female rats increases rate of weight gain but not body fat content
OBJECTIVE: To examine the effects of short-term repeated weight cycling (WC) above and below the baseline (BL) body weight (BW) on body weight regulation, feeding efficiency, and fat content in old
Effects of intermittent food restriction and refeeding on energy efficiency and body fat deposition in sedentary and exercised rats.
It is suggested that weight cycling increases body fat deposition and energy efficiency by decreasing energy expenditure, particularly the TEF, and that exercise training can alleviate the effects of weight cycling on the energy metabolism.


Persistent obesity in rats following a period of consumption of a mixed, high energy diet.
Adult male hooded rats which were offered a mixed, high energy diet for 90 days were hyperphagic and became significantly obese compared to chow‐fed control rats, suggesting that the persisting obesity may not be associated with altered insulin resistance.
Refeeding after fasting in the rat: effects of dietary-induced obesity on energy balance regulation.
Lipogenic enzymes and lipoprotein lipase activity in adipose tissue as well as plasma insulin concentrations were elevated in overfed rats but normalized during refeeding of Chow after fasting, in sharp contrast to nonobese animals subjected to a similar experimental procedure.
Refeeding after fasting in the rat: effects on body composition and food efficiency.
Adult male Sprague-Dawley rats were fasted for 65 h and then refed ad libitum for 8 days, during which time body weight and body composition returned to the levels of nonfasting controls, suggesting that starvation-induced energy conservation processes seem to persist during refeeding.
Effects of severe long-term food deprivation and refeeding on adipose tissue cells in the rat.
Severe, long-term food deprivation followed by refeeding causes loss and recovery of stromal-vascular cells in adipose tissue but no loss of fat cells.
Oxygen consumption and locomotor activity during restricted feeding and realimentation.
It is suggested that metabolic adaptations contribute significantly to the enhanced efficiency of food utilization reported in food-restricted animals during controlled realimentation.
Refeeding after a fast in rats: effects on small intestinal enzymes.
The effect of resuming food intake after a period of starvation (refeeding) on the specific activities of selected rat intestinal enzymes was determined and the overshoot in intestinal enzyme specific activities may help promote the rapid weight gain observed in refed rats.
Effects of refeeding on adipocyte metabolism in the rat.
The results confirm previous results showing elevated metabolism after fasting-refeeding, and demonstrate that this is an adaptation of fat-cell metabolism rather than a consequence of a higher cellular density of adipose tissue after fasted-refed with smaller fat cells.